Drug Uses

Transderm Scop is used to relieve nausea, vomiting, and dizziness associated with motion sickness. Transderm Scop is an anticholinergic medicine. Anticholinergics have many effects in the body. For example, they decrease the secretion of fluids, slow the stomach and intestine, and dilate the pupils.

How Taken

Transderm Scop comes as a patch to be placed on the skin behind your ear. Apply one patch to a clean, dry, hairless area behind the ear. The patch should be applied at least 4 hours before its effects will be needed. Each patch is good for 3 days. At the end of 3 days or when the Transderm Scop patch is no longer needed, remove the patch and throw it away. Wrap the patch in tissue or paper to avoid exposing anyone else to the remaining medication. Wash your hands and the area behind your ear thoroughly to remove any traces of Transderm Scop from the area. If a new patch needs to be applied, place a fresh patch on the hairless area behind your other ear.

Warnings/Precautions

Before using this medication, tell your doctor if you have kidney disease, liver disease, an enlarged prostate, difficulty urinating, bladder problems, or glaucoma. Transderm Scop is in the FDA pregnancy category C. This means that it is not known whether Transderm Scop will harm an unborn baby. Do not use Transderm Scop without first talking to your doctor if you are pregnant. It is not known whether Transderm Scop passes into breast milk. Do not use Transderm Scop without first talking to your doctor if you are breast-feeding a baby. Transderm Scop is not recommended for children use. Children are much more sensitive to the side effects of scopolamine.

Missed Dose

Remove the old patch as soon as you remember and apply a new patch to the same area behind the other ear. If it is almost time for the next dose, skip the missed dose altogether. Never take a double dose of Transderm Scop.

Possible Side Effects

Stop using Transderm Scop and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives). Other, less serious side effects may be more likely to occur. Continue to use Transderm Scop and talk to your doctor if you experience drowsiness; dry mouth, nose, or throat; restlessness, excitation, nervousness, or insomnia; blurred vision; dizziness; decreased appetite, nausea, or vomiting; difficulty urinating; or an irregular or fast heartbeat. Nausea, vomiting, dizziness, headache, and poor coordination have been reported when treatment lasting more than 3 days is discontinued. If you use Transderm Scop for more than 3 days, be aware that these side effects may occur when you stop. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Should be stored at controlled room temperature between 20°C - 25°C (68°F - 77°F).

Overdose

Seek emergency medical attention. Symptoms of a Transderm Scop overdose include drowsiness, dizziness, agitation, excitability, seizures or convulsions, hallucinations, and death.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Transderm Scop may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are using Transderm Scop.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

Other info about Transderm-scop at Wikipedia.org and other resources:

Structural classification of proteins and structural genomics: new insights into protein folding and evolution
During the past decade, the Protein Structure Initiative (PSI) centres have become major contributors of new families, superfamilies and folds to the Structural Classification of Proteins (SCOP) database. The PSI results have increased the diversity of protein structural space and accelerated our understanding of it. This review article surveys a selection of protein structures determined by the Joint Center for Structural Genomics (JCSG). It presents previously undescribed β-sheet architectures such as the double barrel and spiral β-roll and discusses new examples of unusual topologies and peculiar structural features observed in proteins characterized by the JCSG and other Structural Genomics centres. (Source: Acta Crystallographica Section F)

Automatic structure classification of small proteins using random forest
Conclusions: The utility of random forest in classifying domains from the place-holder classes of SCOP to the true Class, Fold, Super-family or Family levels is demonstrated. Issues such as introduction of a new structural level in SCOP and the merger of singleton levels can also be addressed using random forest. A real-world scenario is mimicked by predicting the classification for those protein structures from the PDB, which are yet to be assigned to the SCOP classification hierarchy. (Source: BMC Bioinformatics - Latest articles)

dConsensus: a tool for displaying domain assignments by multiple structure-based algorithms and for construction of a consensus assignment
Conclusion: dConsensus provides a comprehensive assignment of protein domains. For the first time, seven algorithmic methods are brought together with no need to access each method separately via a webserver or local copy of the software. This aggregation permits a consensus domain assignment to be computed. Comparison viewing of the consensus and choice methods provides the user with insights into the fundamental units of protein structure so important to the study of evolutionary and functional relationships. (Source: BMC Bioinformatics - Latest articles)

Recognition of beta-structural motifs using hidden Markov models trained with simulated evolution
Motivation: One of the most successful methods to date for recognizing protein sequences that are evolutionarily related, has been profile hidden Markov models. However, these models do not capture pairwise statistical preferences of residues that are hydrogen bonded in β-sheets. We thus explore methods for incorporating pairwise dependencies into these models. Results: We consider the remote homology detection problem for β-structural motifs. In particular, we ask if a statistical model trained on members of only one family in a SCOP β-structural superfamily, can recognize members of other families in that superfamily. We show that HMMs trained with our pairwise model of simulated evolution achieve nearly a median 5% improvement in AUC for β-structural motif recognitio...

The Protein-DNA Interface database
(PDIdb) is a repository containing relevant structural information of Protein-DNA complexes solved by X-ray crystallography and available at the Protein Data Bank. The database includes a simple functional classification of the protein-DNA complexes that consists of three hierarchical levels: Class, Type and Subtype. This classification has been defined and manually curated by humans based on the information gathered from several sources that include PDB, PubMed, CATH, SCOP and COPS. The current version of the database contains only structures with resolution of 2.5 A or higher, accounting for a total of 922 entries. The major aim of this database is to contribute to the understanding of the main rules that underlie the molecular recognition process between DNA and proteins. To this end, ...